Day: April 25, 2025

Gene signatures associated with increased efficacy of micvotabart pelidotin (MICVO) due to greater linker cleavage were identified based on differential gene expression analysis of PDX responders/non-responders Mouse analog of MICVO in a syngeneic model indicated strong activity of the cytotoxic Auristatin0101 payload and potential for MICVO monotherapy to drive immunogenic cell death, a key hypothesis for MICVO’s mechanism Combination of a mouse analog of MICVO and anti-PD-1 therapy in a syngeneic model resulted in enhanced tumor clearance and longer immunological memory compared to either treatment alone Totality of pre-clinical data presented at AACR 2025 strongly support MICVO’s unique, three-pronged mechanism of action of driving anti-tumor activity via direct tumor killing, bystander effect and immunogenic cell death, further reinforcing...

– Data to be presented at AACR 2025 Annual Meeting suggest the combination of ALX Oncology’s investigational CD47-blocker, evorpacept, plus rituximab and lenalidomide (R2) was well-tolerated and demonstrated promising anti-tumor activity – Combination generated complete responses (CR) in 83% of patients with indolent relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL) comparing favorably to 34% historical CR rate with R2 alone – Phase 2 portion of trial in patients with previously untreated indolent NHL (iNHL) is ongoing and has completed enrollment SOUTH SAN FRANCISCO, Calif., April 25, 2025 (GLOBE NEWSWIRE) — ALX Oncology Holdings Inc., (“ALX Oncology” or the “Company”) (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients’...

[Ad hoc announcement pursuant to Art. 53 LR] This press release is also available in Français (pdf) and Deutsch (pdf) ………….Vevey, April 25, 2025 Nestlé appoints Jeff Hamilton as CEO Zone Americas, Steve Presley to retire from the companyNestlé’s Board of Directors has appointed Jeff Hamilton, currently Business Head of Purina PetCare Zone Europe, as Chief Executive Officer Zone Americas (AMS) and member of the Group Executive Board, effective 1 July 2025.  After almost 30 years of service, Steve Presley, Executive Vice President and CEO Zone AMS, will retire from the company. He will leave the Executive Board and his role as CEO Zone AMS on 30 April 2025.  Laurent Freixe, CEO Nestlé S.A., commented, “We are very grateful to Steve for his many years of dedicated service to our company and extend our best...

American Rebel Holdings IncAndy Ross Harnesses Media Appearance on NBC-TV West Palm BeachFrom Song to Strategy: American Rebel’s CEO Andy Ross Shares the Brand’s Journey with Sunshine Spotlight Host Fiona Daghir Detailing the Journey of America’s Patriotic Brand to Becoming the Next Great American Success Story. West Palm Beach, FL, April 25, 2025 (GLOBE NEWSWIRE) — American Rebel Holdings, Inc. (NASDAQ: AREB) (“American Rebel” or the “Company”), creator of American Rebel Beer (americanrebelbeer.com) and a designer, manufacturer, and marketer of branded safes, personal security and self-defense products and apparel (americanrebel.com), is pleased to share its CEO Andy Ross’ TV interview on the NBC-TV affiliate in West Palm Beach, Florida – WPTV. Sunshine Spotlight host Fiona Daghir (instagram.com/fionadaghir)...

The seven-story community offers 356 modern residences and resort-style amenities in the heart of Stamford STAMFORD, Conn., April 25, 2025 (GLOBE NEWSWIRE) — Toll Brothers Apartment Living®, the rental subsidiary of Toll Brothers, Inc. (NYSE: TOL), the nation’s leading builder of luxury homes, in partnership with CrossHarbor Capital Partners, announces the grand opening of Julius, a luxury apartment community in downtown Stamford, Connecticut. Financed with a $94 million construction loan facility from Capital One, N.A. as agent and Comerica Bank, Julius welcomed its first residents in September 2024. The community celebrated its grand opening this week with a ribbon-cutting event attended by development partners, local officials, and community members. Located at 777 Summer Street, Julius offers 356 thoughtfully designed...

LONGUEUIL, Québec, April 25, 2025 (GLOBE NEWSWIRE) — Greenheart Gold Inc. (TSXV: GHRT; OTCQB: GHRTF) (the “Company” or “Greenheart Gold”) is pleased to announce that it has filed its annual financial statements and management discussion and analysis for the initial period from April 19, 2024 to December 31, 2024 (the “Annual Filings”). The Annual Filings are available on SEDAR+ at www.sedarplus.ca and on the Company’s website at www.greenheartgold.com. As at December 31, 2024, the Company’s cash position totaled $46.4 million which includes the proceeds from the bought deal private placement completed in October 2024 for aggregate gross proceeds of $36.0 million. A total amount of $2.4 million was spent on exploration and evaluation during the initial period ending December 31, 2024. On April 23, 2025, the Company decided to terminate...

HAMILTON, Bermuda, April 25, 2025 (GLOBE NEWSWIRE) — AM Best has revised the outlook of the rated operating subsidiaries of SiriusPoint Ltd (“SiriusPoint” or “the Company”) (Bermuda) [NYSE: SPNT] to Positive from Stable, citing the Company’s “very strong balance sheet”. AM Best has affirmed the Financial Strength Rating of A- (Excellent) and the Long-Term Issuer Credit Ratings (Long-Term ICR) of “a-” (Excellent) of SiriusPoint’s rated operating subsidiaries. Additionally, the rating agency has affirmed the Long-Term ICR of “bbb-” (Good) of SiriusPoint. AM Best said the revision of the outlook to Positive from Stable reflects SiriusPoint’s improved balance sheet strength following actions taken by management including the derisking of the investment portfolio, reduction in catastrophe exposure, and the recent buy-back of shares...