Skip to main content

Crown Bioscience Expands PDX Collection with Acquisition of Unique Models from Leading Academic Medical Centers

Written by Customer Service on . Posted in Public Companies.

SAN DIEGO, April 02, 2020 (GLOBE NEWSWIRE) — Crown Bioscience today announced the strategic expansion of their PDX collection through new agreements with CoMotion at the University of Washington and Dana-Farber Cancer Institute. These agreements will provide highly needed prostate cancer and lymphoma models, respectively, to the oncology drug development community.
PDX models are the most translatable preclinical in vivo models currently available and are the model of choice for preclinical oncology drug discovery and development. However, certain PDXs can be difficult to derive from specific indications, including prostate cancer, while other clinically relevant mutations are underrepresented within current PDX collections.CrownBio’s license with CoMotion at the University of Washington will significantly expand the number of prostate cancer PDX models available to the market. Augmenting CrownBio’s established prostate cancer PDX collection, this new panel of LuCaP PDXs will provide a broad range of clinically relevant models, including difficult to treat castration-resistant prostate cancer, PDX with resistance to targeted agents such as abiraterone and enzalutamide, and models with disease relevant androgen receptor expression profiles including Arv7.The collaboration with Dana-Farber Cancer Institute will in turn bring a wide variety of lymphomas to CrownBio’s portfolio, including T/NK, mantle cell, and follicular lymphomas, as well as DLBCL from refractory or relapsed patients. Models featuring common drug targets are also included, such as brain cancer PDX with IDH1 mutations and NSCLC SCC PDX featuring receptor tyrosine kinase alterations essential to targeted drug discovery.“Through these exciting agreements we’re able to provide well-characterized PDX to research areas where more models were greatly needed,” said Dr. Davy Ouyang, Vice President, Scientific Research & Innovation of CrownBio. “CrownBio is well established as the global leader in PDX technology, and our collection of Western models will be significantly strengthened through these additions, allowing our global customer base greater access to the latest cutting-edge models.”The new models will now be expanded in-house at CrownBio, biobanked, and characterized, before being made available for a variety of oncology and immuno-oncology studies. This includes efficacy assessment, mouse clinical trials, CAR-T cell therapy assessment, humanization, and organoid development.About Crown Bioscience Inc.Crown Bioscience, a JSR Life Sciences company, is a global drug discovery and development service company providing translational platforms to advance oncology, inflammation, and metabolic disease research. With an extensive portfolio of relevant models and predictive tools, Crown Bioscience enables clients to deliver superior clinical candidates. For more information, visit:https://www.crownbio.comhttps://www.jsrlifesciences.comAbout the University of Washington and CoMotionRanked by Reuters as the #1 most innovative public university in the world, the University of Washington (UW) is a leading recipient of federal funding research, producing innovations that have the power to change the world—from biofuel alternatives, to more effective treatments for Alzheimer’s disease and brain cancer, to purification technology for drinking water in the developing world. CoMotion at the UW is the collaborative innovation hub dedicated to expanding the global economic and societal impact of the UW community. By developing and connecting to local and global innovation ecosystems, CoMotion helps innovators achieve the greatest impact from their ideas and discoveries.
Find more information at https://comotion.uw.edu.Media Enquiries:Crown Bioscience
Jody Barbeau
Crown Bioscience Inc.
pr@crownbio.comCoMotion at the University of Washington
Donna O’Neill
donnao3@uw.edu

Disclaimer & Cookie Notice

Welcome to GOLDEA services for Professionals

Before you continue, please confirm the following:

Professional advisers only

I am a professional adviser and would like to visit the GOLDEA CAPITAL for Professionals website.

Cookie Notice

We use cookies to improve your experience on our website

Information we collect about your use of Goldea Capital website

Goldea Capital website collects personal data about visitors to its website.

When someone visits our websites, we use a third party service, Google Analytics, to collect standard internet log information (such as IP address and type of browser they’re using) and details of visitor behavior patterns. We do this to allow us to keep track of the number of visitors to the various parts of the sites and understand how our website is used. We do not make any attempt to find out the identities or nature of those visiting our websites. We won’t share your information with any other organizations for marketing, market research or commercial purposes and we don’t pass on your details to other websites.

Use of cookies
Cookies are small text files that are placed on your computer or other device by websites that you visit. They are widely used to make websites work, or work more efficiently, as well as to provide information to the owners of the site.