Addex to Receive Additional $800K Funding from Indivior for GABAB PAM Addiction Program
Geneva, Switzerland, December 20, 2019 – Addex Therapeutics (SIX: ADXN), a leading allosteric modulation-based drug discovery and development company, today announced that Indivior PLC (LON: INDV) will provide Addex with a second additional $800,000 in 2019 to accelerate research progess in their collaboration to develop further oral gamma-aminobutyric acid subtype B (GABAB) positive allosteric modulator (PAM) compounds for the treatment of addiction. Under the terms of the original agreement signed with Indivior in January 2018, Addex received a $5 million upfront and a minimum of $2 million per year of research funding for 2 years. Activation of the GABAB pathway is clinically and commercially validated but to date treatment is limited due to side effects. Targeting GABAB with PAMs could produce less adverse effects and lead to less tolerance compared to direct agonists.Addex Therapeutics is a clinical-stage pharmaceutical company focused on the development and commercialization of an emerging class of novel orally available small molecule drugs known as allosteric modulators for neurological disorders. Allosteric modulators offer several potential advantages over conventional non-allosteric molecules and may offer an improved therapeutic approach to conventional “orthosteric” small molecule or biological drugs. Addex’s allosteric modulator drug discovery platform targets receptors and other proteins that are recognized as essential for therapeutic intervention. Addex’s lead drug candidate, dipraglurant (mGlu5 negative allosteric modulator or NAM), has successfully completed a Phase 2a POC in Parkinson’s disease levodopa-induced dyskinesia (PD-LID), and is being prepared to enter registration trials for PD-LID. In parallel, dipraglurant’s therapeutic use in dystonia is being investigated in preclinical models. Addex’s second clinical program, ADX71149 (mGlu2 positive allosteric modulator or PAM) is being developed in collaboration with Janssen Pharmaceuticals, Inc for the treatment of epilepsy. In addition, Addex’s GABAB PAM program has been licensed to Indivior PLC for the treatment of addiction. Preclinical programs include GABAB PAM for CMT1A, mGlu7 NAM for PTSD, mGlu2 NAM for mild neurocognitive disorders, mGlu4 PAM for Parkinson’s disease and mGlu3 PAM for neurodegenerative disorders.
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